The application of salicin extracted from white willow bark in the field of cosmetics

The miraculous extract of white willow bark, salicin, which can reduce inflammation, acne, and oil damage

Introduction to White Willow bark Extract
Raw material source:
Salix babylonica is a deciduous tree in the willow family, with a height of 10-12 meters. There are long and drooping branches, the lower branch is brown and hairless, and slightly hairy when young. It can be harvested throughout the year and used to extract bark, known as white willow bark.
2, Physical properties of salidroside extracted from white willow bark
Commonly used name: Salicylic acid glycoside
English name salicin
English alias D-Salicin (1.05055); alpha-hydroxy-o-tolyl beta-D-glucopyranoside; 2-(hydroxymethyl)phenyl beta-D-glucopyranoside; White Willow Bark Extract; Salicin
CAS number 138-52-3
Molecular weight 286.278
Density 1.5 ± 0.1 g/cm3
Boiling point 549.1 ± 50.0 ° C at 760 mmHg
Molecular formula C13H18O7
Melting point 196-202 ° C
The appearance has hygroscopicity. Solubility in water: 36 g/L (15°C), 250 g/L (60 ° C), soluble in pyridine, alkali, and glacial acetic acid, almost insoluble in ether and chloroform. The aqueous solution is neutral and has a bitter taste. It is stimulating. Density: 1.434 Melting point: 199-202 ℃
Water solubility 36 g/L (15 º C), 250 g/L (60 ºC)
chemical property
salicin is a white crystal; Taste bitter; Melting point 199-202 ℃, specific optical rotation [α] -45.6 ° (0.6 g/100 cm3 anhydrous ethanol); Soluble in water, easily soluble in boiling water, difficult to dissolve in ethanol (1:90), insoluble in ether or chloroform, but soluble in alkaline solutions, pyridine or glacial acetic acid. Its aqueous solution exhibits a neutral reaction, with no free phenolic hydroxyl groups in the molecule, and belongs to the class of phenolic glycosides. Hydrolysis by dilute acid or bitter almond enzyme can produce glucose and salicylate. The molecular formula of salicylic alcohol is C7H8O2; It is an oblique colorless needle crystal; Melting point of 86-87 ℃; Sublimation at 100 ℃; Soluble in water and benzene, easily soluble in ethanol, ether, chloroform; It turns red when encountering sulfuric acid.
3, Specification for salicin in White Willow bark Extract
 White Willow Bark extract
[Product Specifications]: 10% -99% (15% brownish yellow, high ash content, 25% brownish yellow, high ash content, 30% yellow, high ash content, 50% light yellow, high ash content, 80% off white, low ash content, 98% white, low ash content)
[Product Source]: Salix BabylonicaL
【 Application Form 】: Powder
【 Storage time 】: 24 months
[Product Packaging]: 1kg/bag 25kg/barrel
[Testing Method]: HPLC
【 Storage Method 】: Keep in a dry and cool place, avoid direct sunlight and high temperatures.
4, The efficacy and application of salicin extracted from white willow bark in the field of cosmetics
1. Treat fever, cold, and infection
As a "natural aspirin", salicin is used to treat mild fever, cold, infection (influenza), acute and chronic rheumatic discomfort, headache and pain caused by inflammation. Aspirin (acetylsalicylic acid), as a synthetic substitute for salidroside, has potential gastrointestinal hazards and side effects. As its natural form, salidroside can be harmlessly converted into salicylic acid through the gastrointestinal system in the blood and liver. The conversion process takes several hours, so the results will not be immediately felt by the human body, but the general efficacy will last for several hours.
2. Reduce arthritis pain and lower back pain
Salicylic acid glycosides are considered to be the source of anti-inflammatory and pain relieving abilities in white willow bark. The pain relieving ability of white willow bark usually takes effect slowly but lasts longer than that of regular aspirin products. An experiment found that a type of herbal compound containing 100ng salidroside can effectively improve the pain relief ability of arthritis patients after continuous use for two months. Another experiment found that consuming 1360mg of white willow bark extract (containing 240mg of salidroside) daily for two weeks can have better efficacy in treating joint pain and/or arthritis. The use of high-dose white willow bark extract may also help alleviate lower back pain. A four week experiment found that a white willow bark extract containing 240mg of salidroside can effectively alleviate the worsening of lower back pain.
3. It can soften keratin, make it fall off, enhance skin smoothness, etc. Dealing with acne and pimples: softening and shedding keratin, reducing pore blockage, has a good effect on adolescent acne and common acne. Dealing with blackheads and keratosis around hair: can soften and remove the top of blackheads and keratin cysts, temporarily improving skin smoothness; By shedding keratin, excess keratin around the hair is removed, relieving keratosis around the hair (chicken skin), but the effect on organic enlarged pores is not satisfactory; Skin replacement surgery: Medical use, using a high concentration solution to quickly remove the epidermis, used for the treatment of moderate to severe acne, ichthyosis, and other conditions. Whitening: Accelerates the shedding of the stratum corneum, causing the melanin in the keratinocytes to also shed, revealing a lighter colored skin tone. Soften the skin: Thinning the stratum corneum makes the skin feel softer.
The main active ingredient in the extract of white willow bark is Salicin. Salicylic acid glycoside has aspirin like properties and is an effective anti-inflammatory ingredient traditionally used to heal wounds and relieve muscle pain. Research has found that salidroside is an inhibitor of NADH oxidase, which has anti-aging, exfoliating, and acne removing effects in cosmetics. It can increase skin radiance and elasticity, reduce pigmentation, and increase skin moisture.

Active ingredient  : Salicin  
1. Anti aging
Salicylic acid not only affects the regulation of genes in the skin, but also regulates gene groups related to the biological processes of skin aging, which are known as functional 'youthful gene groups'. In addition, salicin plays an important role in the production and maintenance of collagen, one of the key proteins in the skin, thus increasing skin elasticity and achieving anti wrinkle effects.
2. Exfoliation
Salicylic acid has the effect of gently removing dead skin cells on the surface of the skin, accelerating the shedding of aging skin cells, regulating the physiological activity of the skin's stratum corneum, and making the skin uniform and radiant.
3. Antibacterial, anti-inflammatory and acne removing
Salicylic acid glycoside, due to its aspirin like properties, has certain anti-inflammatory effects and can be used to alleviate facial acne, herpetic inflammation, and sunburn.