Fourstamen Stephania Root extract Tetrandrine 98%

Tetrandrine is a plant alkaloid with a wide range of pharmacological effects. It is extracted from Fourstamen Stephania Root extract and has important research value in the fields of anti-inflammatory, anti-fibrosis and anti-tumor. With the in-depth study of its mechanism of action in modern medicine, Tetrandrine is expected to provide new ideas and solutions for the treatment of various chronic diseases. It is a colorless needle crystal, insoluble in water and petroleum ether, easily soluble in organic solvents such as ethanol, acetone, ethyl acetate, ether and chloroform, and dilute acid water, soluble in benzene, mp216℃, with a double melting point phenomenon. Those crystallized from acetone melt at about 150℃ and solidify after heating, and re-melt at 213℃.

Anti-inflammatory effect
Tetrandrine can reduce inflammatory response by inhibiting the expression of inflammatory factors (such as TNF-α, IL-6), and has potential in the treatment of inflammatory diseases such as arthritis and asthma.

Anti-tumor effect
Studies have shown that Tetrandrine can induce apoptosis of cancer cells, inhibit cancer cell proliferation and metastasis, and especially show good anti-cancer activity in various cancer models such as liver cancer, breast cancer, and lung cancer.

Anti-fibrosis effect
Tetrandrine has shown significant effects in the treatment of diseases such as pulmonary fibrosis and liver fibrosis, slowing down the fibrosis process by inhibiting the deposition of collagen and the activation of fibroblasts.

Calcium channel blocking effect
As a calcium channel blocker, Tetrandrine can regulate intracellular calcium ion concentration, help smooth muscle relaxation, lower blood pressure, and improve cardiovascular function.

Immunomodulatory effect
Tetrandrine can regulate immune response by inhibiting T cell activation and reducing the release of inflammatory mediators, and has potential value in the treatment of autoimmune diseases.

Anti-infective effect
It shows certain activity in antiviral and anti-bacterial infection, which helps prevent and treat certain infectious diseases.

1. Immune system diseases Tetrandrine can significantly inhibit the development of arthritis and has a stronger effect than aspirin. It can be used to treat rheumatoid arthritis.
2. Cardiovascular system diseases Tetrandrine not only has a calcium antagonist effect, but also can inhibit the T-type and L-type calcium channels of ventricular myocytes. It also interacts with M receptors and can block calcium-activated potassium channels, becoming a treatment for paroxysmal supraventricular tachycardia.
3. Digestive system Tetrandrine has a certain effect in protecting liver cells and resisting liver fibrosis.
4. Ophthalmic diseases Tetrandrine is used to treat ocular inflammation, including uveitis, keratitis and the retinal lesions caused by them.
5. Others Tetrandrine has a significant antagonistic effect on the acute nephrotoxic effect caused by streptomycin, can reduce the apoptosis and proliferation of renal tubular epithelial cells, protect renal function, and has a protective effect on acute ischemia-reperfusion renal injury. It can significantly reduce serum creatinine and urea nitrogen levels, improve glomerular filtration rate and renal plasma flow, and delay the development of glomerular sclerosis.

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Storage Situation

Stored in a cool and dry well-closed container, keep away from moisture and strong light / heat.

Shelf Life

two years under well Storage situation and stored away from direct sun light.

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